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'''SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF''' | '''SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF''' | ||
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[[Category: Medof, M E.]] | [[Category: Medof, M E.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
[[Category: | [[Category: Alternative splicing]] | ||
[[Category: | [[Category: Blood group antigen]] | ||
[[Category: | [[Category: Complement pathway]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Gpi-anchor]] | ||
[[Category: | [[Category: Immune response]] | ||
[[Category: | [[Category: Immune system]] | ||
[[Category: | [[Category: Innate immunity]] | ||
[[Category: | [[Category: Lipoprotein]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Polymorphism]] | ||
[[Category: | [[Category: Scr2/3 of daf fitted into cryoem density of cvb3-rd complexed with daf]] | ||
[[Category: | [[Category: Sushi]] | ||
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Revision as of 15:58, 4 May 2008
SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF
OverviewOverview
Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.
About this StructureAbout this Structure
2QZH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:17804498 Page seeded by OCA on Sun May 4 15:58:28 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Single protein
- Bowman, V D.
- Chipman, P R.
- Hafenstein, S.
- Kelly, C M.Bator.
- Lin, F.
- Medof, M E.
- Rossmann, M G.
- Alternative splicing
- Blood group antigen
- Complement pathway
- Glycoprotein
- Gpi-anchor
- Immune response
- Immune system
- Innate immunity
- Lipoprotein
- Membrane
- Polymorphism
- Scr2/3 of daf fitted into cryoem density of cvb3-rd complexed with daf
- Sushi