2qzd: Difference between revisions

Revision as of 15:57, 4 May 2008

Fitted structure of SCR4 of DAF into cryoEM density

OverviewOverview

Many entero-, parecho-, and rhinoviruses use immunoglobulin (Ig)-like receptors that bind into the viral canyon and are required to initiate viral uncoating during infection. However, some of these viruses use an alternative or additional receptor that binds outside the canyon. Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like molecule that binds into the viral canyon, and decay-accelerating factor (DAF) have been identified as cellular receptors for coxsackievirus B3 (CVB3). A cryoelectron microscopy reconstruction of a variant of CVB3 complexed with DAF shows full occupancy of the DAF receptor in each of 60 binding sites. The DAF molecule bridges the canyon, blocking the CAR binding site and causing the two receptors to compete with one another. The binding site of DAF on CVB3 differs from the binding site of DAF on the surface of echoviruses, suggesting independent evolutionary processes.

About this StructureAbout this Structure

2QZD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Interaction of decay-accelerating factor with coxsackievirus B3., Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG, J Virol. 2007 Dec;81(23):12927-35. Epub 2007 Sep 5. PMID:17804498 Page seeded by OCA on Sun May 4 15:57:48 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2qzd.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2qzd |SIZE=350|CAPTION= <scene name='initialview01'>2qzd</scene>
+The line below this paragraph, containing "STRUCTURE_2qzd", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= CD55, CR, DAF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2qzd|  PDB=2qzd  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qzd OCA], [http://www.ebi.ac.uk/pdbsum/2qzd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qzd RCSB]</span>
-}}
 '''Fitted structure of SCR4 of DAF into cryoEM density'''
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 [[Category: Medof, M E.]]
 [[Category: Rossmann, M G.]]
-[[Category: alternative splicing]]
+[[Category: Alternative splicing]]
-[[Category: blood group antigen]]
+[[Category: Blood group antigen]]
-[[Category: complement pathway]]
+[[Category: Complement pathway]]
-[[Category: glycoprotein]]
+[[Category: Glycoprotein]]
-[[Category: gpi-anchor]]
+[[Category: Gpi-anchor]]
-[[Category: immune response]]
+[[Category: Immune response]]
-[[Category: immune system]]
+[[Category: Immune system]]
-[[Category: innate immunity]]
+[[Category: Innate immunity]]
-[[Category: lipoprotein]]
+[[Category: Lipoprotein]]
-[[Category: membrane]]
+[[Category: Membrane]]
-[[Category: polymorphism]]
+[[Category: Polymorphism]]
-[[Category: scr4 of daf from 1ojv fitted into cryoem density]]
+[[Category: Scr4 of daf from 1ojv fitted into cryoem density]]
-[[Category: sushi]]
+[[Category: Sushi]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:57:48 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:59 2008''