2qr7: Difference between revisions

Revision as of 15:28, 4 May 2008

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative

OverviewOverview

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

About this StructureAbout this Structure

2QR7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304 Page seeded by OCA on Sun May 4 15:28:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2qr7.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2qr7 |SIZE=350|CAPTION= <scene name='initialview01'>2qr7</scene>, resolution 2.00&Aring;
+The line below this paragraph, containing "STRUCTURE_2qr7", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= Rps6ka3, Rps6ka-rs1, Rsk2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+-->
-|DOMAIN=
+{{STRUCTURE_2qr7|  PDB=2qr7  |  SCENE=  }}
-|RELATEDENTRY=[[2qr8|2QR8]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qr7 OCA], [http://www.ebi.ac.uk/pdbsum/2qr7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qr7 RCSB]</span>
-}}
 '''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative'''
@@ Line 29: / Line 26: @@
 [[Category: Malakhova, M.]]
 [[Category: Tereshko, V.]]
-[[Category: atp-binding]]
+[[Category: Atp-binding]]
-[[Category: autoinhibitory]]
+[[Category: Autoinhibitory]]
-[[Category: kinase domain]]
+[[Category: Kinase domain]]
-[[Category: nucleotide-binding]]
+[[Category: Nucleotide-binding]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: rsk2]]
+[[Category: Rsk2]]
-[[Category: serine/threonine-protein kinase]]
+[[Category: Serine/threonine-protein kinase]]
-[[Category: transferase]]
+[[Category: Transferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:28:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:52:22 2008''