2ph0: Difference between revisions

Revision as of 13:05, 4 May 2008

Crystal structure of the Q6D2T7_ERWCT protein from Erwinia carotovora. NESG target EwR41.

OverviewOverview

We report here the crystal structure at 2.0 A resolution of the AGR_C_4470p protein from the Gram-negative bacterium Agrobacterium tumefaciens. The protein is a tightly associated dimer, each subunit of which bears strong structural homology with the two domains of the heme utilization protein ChuS from Escherichia coli and HemS from Yersinia enterocolitica. Remarkably, the organization of the AGR_C_4470p dimer is the same as that of the two domains in ChuS and HemS, providing structural evidence that these two proteins evolved by gene duplication. However, the binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function. This is supported by the presence of two homologs of AGR_C_4470p in E. coli, in addition to the ChuS protein.

About this StructureAbout this Structure

2PH0 is a Single protein structure of sequence from Pectobacterium carotovorum. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens., Vorobiev SM, Neely H, Seetharaman J, Ma LC, Xiao R, Acton TB, Montelione GT, Tong L, Protein Sci. 2007 Mar;16(3):535-8. PMID:17322535 Page seeded by OCA on Sun May 4 13:05:22 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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- {{Structure
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-|GENE= ECA3008 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=554 Pectobacterium carotovorum])
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-}}
 '''Crystal structure of the Q6D2T7_ERWCT protein from Erwinia carotovora. NESG target EwR41.'''
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 [[Category: Vorobiev, S M.]]
 [[Category: Xiao, R.]]
-[[Category: erwct]]
+[[Category: Erwct]]
-[[Category: ewr41]]
+[[Category: Ewr41]]
-[[Category: nesg]]
+[[Category: Nesg]]
-[[Category: northeast structural genomics consortium]]
+[[Category: Northeast structural genomics consortium]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi-2]]
+[[Category: Psi-2]]
-[[Category: q6d2t7]]
+[[Category: Q6d2t7]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: unknown function]]
+[[Category: Unknown function]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:05:22 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:35:47 2008''