2pbn: Difference between revisions

Revision as of 12:47, 4 May 2008

Crystal structure of the human tyrosine receptor phosphate gamma

OverviewOverview

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

About this StructureAbout this Structure

2PBN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037 Page seeded by OCA on Sun May 4 12:47:37 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2pbn.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2pbn |SIZE=350|CAPTION= <scene name='initialview01'>2pbn</scene>, resolution 1.700&Aring;
+The line below this paragraph, containing "STRUCTURE_2pbn", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+301'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= PTPRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00047 PTPc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00194 PTPc]</span>
+{{STRUCTURE_2pbn|  PDB=2pbn  |  SCENE=  }}
-|RELATEDENTRY=[[2hy3|2HY3]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbn OCA], [http://www.ebi.ac.uk/pdbsum/2pbn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pbn RCSB]</span>
-}}
 '''Crystal structure of the human tyrosine receptor phosphate gamma'''
@@ Line 38: / Line 35: @@
 [[Category: Smith, D.]]
 [[Category: Wasserman, S.]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: new york structural genomix research consortium]]
+[[Category: New york structural genomix research consortium]]
-[[Category: nysgxrc]]
+[[Category: Nysgxrc]]
-[[Category: protein structure initiative]]
+[[Category: Protein structure initiative]]
-[[Category: psi-2]]
+[[Category: Psi-2]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:47:37 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:33:56 2008''