2orh: Difference between revisions

Revision as of 11:31, 4 May 2008

Directing Macromolecular Conformation Through Halogen Bonds

OverviewOverview

The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665 Page seeded by OCA on Sun May 4 11:31:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2orh.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2orh |SIZE=350|CAPTION= <scene name='initialview01'>2orh</scene>, resolution 1.90&Aring;
+The line below this paragraph, containing "STRUCTURE_2orh", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2orh|  PDB=2orh  |  SCENE=  }}
-|RELATEDENTRY=[[2orf|2ORF]], [[2org|2ORG]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2orh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2orh OCA], [http://www.ebi.ac.uk/pdbsum/2orh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2orh RCSB]</span>
-}}
 '''Directing Macromolecular Conformation Through Halogen Bonds'''
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 ==About this Structure==
-ORH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORH OCA].
 ==Reference==
 Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17379665 17379665]
-[[Category: Protein complex]]
 [[Category: Hays, F A.]]
 [[Category: Ho, P S.]]
 [[Category: Voth, A R.]]
-[[Category: dna holliday junction]]
+[[Category: Dna holliday junction]]
-[[Category: halogen bond]]
+[[Category: Halogen bond]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:31:10 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:07 2008''