2oq1: Difference between revisions

Revision as of 11:25, 4 May 2008

Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

OverviewOverview

The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.

About this StructureAbout this Structure

2OQ1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor., Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, et al., Nature. 1995 Sep 7;377(6544):32-8. PMID:7659156 Page seeded by OCA on Sun May 4 11:25:31 2008

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OCA

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 [[Image:2oq1.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2oq1 |SIZE=350|CAPTION= <scene name='initialview01'>2oq1</scene>, resolution 1.9&Aring;
+The line below this paragraph, containing "STRUCTURE_2oq1", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oq1 OCA], [http://www.ebi.ac.uk/pdbsum/2oq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oq1 RCSB]</span>
-}}
 '''Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide'''
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 [[Category: Morgenstern, J.]]
 [[Category: Ram, M K.]]
-[[Category: tandem sh2 domain]]
+[[Category: Tandem sh2 domain]]
-[[Category: tyrosine kinase]]
+[[Category: Tyrosine kinase]]
-[[Category: zap-70]]
+[[Category: Zap-70]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:25:31 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:21:27 2008''