2of2: Difference between revisions

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[[Image:2of2.gif|left|200px]]
[[Image:2of2.gif|left|200px]]


{{Structure
<!--
|PDB= 2of2 |SIZE=350|CAPTION= <scene name='initialview01'>2of2</scene>, resolution 2.00&Aring;
The line below this paragraph, containing "STRUCTURE_2of2", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=547:2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE'>547</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
or leave the SCENE parameter empty for the default display.
|GENE= LCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_2of2| PDB=2of2  | SCENE= }}  
|RELATEDENTRY=[[2of4|2OF4]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2of2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of2 OCA], [http://www.ebi.ac.uk/pdbsum/2of2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2of2 RCSB]</span>
}}


'''crystal structure of furanopyrimidine 8 bound to lck'''
'''crystal structure of furanopyrimidine 8 bound to lck'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Martin, M W.]]
[[Category: Martin, M W.]]
[[Category: kinase domain]]
[[Category: Kinase domain]]
[[Category: lck]]
[[Category: Lck]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:46:24 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:16:51 2008''

Revision as of 10:46, 4 May 2008

File:2of2.gif

Template:STRUCTURE 2of2

crystal structure of furanopyrimidine 8 bound to lck


OverviewOverview

2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.

DiseaseDisease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this StructureAbout this Structure

2OF2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties., Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, DiMauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681 Page seeded by OCA on Sun May 4 10:46:24 2008

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OCA
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