2o8d: Difference between revisions

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[[Image:2o8d.gif|left|200px]]
[[Image:2o8d.gif|left|200px]]


{{Structure
<!--
|PDB= 2o8d |SIZE=350|CAPTION= <scene name='initialview01'>2o8d</scene>, resolution 3.000&Aring;
The line below this paragraph, containing "STRUCTURE_2o8d", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= MSH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MSH6, GTBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
-->
|DOMAIN=
{{STRUCTURE_2o8d|  PDB=2o8d |  SCENE= }}  
|RELATEDENTRY=[[2o8b|2O8B]], [[2o8c|2O8C]], [[2o8e|2O8E]], [[2o8f|2O8F]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8d OCA], [http://www.ebi.ac.uk/pdbsum/2o8d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o8d RCSB]</span>
}}


'''human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair'''
'''human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair'''
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[[Category: Pohlhaus, T J.]]
[[Category: Pohlhaus, T J.]]
[[Category: Warren, J J.]]
[[Category: Warren, J J.]]
[[Category: cancer]]
[[Category: Cancer]]
[[Category: dna damage response]]
[[Category: Dna damage response]]
[[Category: dna mismatch repair]]
[[Category: Dna mismatch repair]]
[[Category: dna mispair]]
[[Category: Dna mispair]]
[[Category: protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: somatic hypermutation]]
[[Category: Somatic hypermutation]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:14:11 2008''

Revision as of 10:26, 4 May 2008

File:2o8d.gif

Template:STRUCTURE 2o8d

human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair


OverviewOverview

Mismatch repair (MMR) ensures the fidelity of DNA replication, initiates the cellular response to certain classes of DNA damage, and has been implicated in the generation of immune diversity. Each of these functions depends on MutSalpha (MSH2*MSH6 heterodimer). Inactivation of this protein complex is responsible for tumor development in about half of known hereditary nonpolyposis colorectal cancer kindreds and also occurs in sporadic tumors in a variety of tissues. Here, we describe a series of crystal structures of human MutSalpha bound to different DNA substrates, each known to elicit one of the diverse biological responses of the MMR pathway. All lesions are recognized in a similar manner, indicating that diversity of MutSalpha-dependent responses to DNA lesions is generated in events downstream of this lesion recognition step. This study also allows rigorous mapping of cancer-causing mutations and furthermore suggests structural pathways for allosteric communication between different regions within the heterodimer.

DiseaseDisease

Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[609309], Mismatch repair cancer syndrome OMIM:[609309], Muir-Torre syndrome OMIM:[609309]

About this StructureAbout this Structure

2O8D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the human MutSalpha DNA lesion recognition complex., Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS, Mol Cell. 2007 May 25;26(4):579-92. PMID:17531815 Page seeded by OCA on Sun May 4 10:26:51 2008

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