2o39: Difference between revisions

Revision as of 10:16, 4 May 2008

Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)

OverviewOverview

Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.

About this StructureAbout this Structure

2O39 is a Protein complex structure of sequences from Homo sapiens and Human adenovirus 11p. Full crystallographic information is available from OCA.

ReferenceReference

Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:17220899 Page seeded by OCA on Sun May 4 10:16:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2o39.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2o39 |SIZE=350|CAPTION= <scene name='initialview01'>2o39</scene>, resolution 2.85&Aring;
+The line below this paragraph, containing "STRUCTURE_2o39", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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+or leave the SCENE parameter empty for the default display.
-|GENE= PIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=343462 Human adenovirus 11p]), CD46, MCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2o39|  PDB=2o39  |  SCENE=  }}
-|RELATEDENTRY=[[1ckl|1CKL]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o39 OCA], [http://www.ebi.ac.uk/pdbsum/2o39 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o39 RCSB]</span>
-}}
 '''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''
@@ Line 30: / Line 27: @@
 [[Category: Reiter, D M.]]
 [[Category: Stehle, T.]]
-[[Category: ad11]]
+[[Category: Ad11]]
-[[Category: adenovirus]]
+[[Category: Adenovirus]]
-[[Category: ccp]]
+[[Category: Ccp]]
-[[Category: cd46]]
+[[Category: Cd46]]
-[[Category: complement control protein]]
+[[Category: Complement control protein]]
-[[Category: fiber knob]]
+[[Category: Fiber knob]]
-[[Category: mcp]]
+[[Category: Mcp]]
-[[Category: membrane cofactor protein]]
+[[Category: Membrane cofactor protein]]
-[[Category: scr]]
+[[Category: Scr]]
-[[Category: short consensus repeat]]
+[[Category: Short consensus repeat]]
-[[Category: virus receptor complex]]
+[[Category: Virus receptor complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 10:16:23 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:06 2008''