2j47: Difference between revisions

Revision as of 08:18, 4 May 2008

BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR

OverviewOverview

Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

About this StructureAbout this Structure

2J47 is a Single protein structure of sequence from Bacteroides thetaiotaomicron. Full crystallographic information is available from OCA.

ReferenceReference

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:17057847 Page seeded by OCA on Sun May 4 08:18:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2j47.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2j47 |SIZE=350|CAPTION= <scene name='initialview01'>2j47</scene>, resolution 1.98&Aring;
+The line below this paragraph, containing "STRUCTURE_2j47", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Gdv+Binding+Site+For+Chain+A'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=GDV:(5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE'>GDV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2j47|  PDB=2j47  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j47 OCA], [http://www.ebi.ac.uk/pdbsum/2j47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j47 RCSB]</span>
-}}
 '''BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR'''
@@ Line 28: / Line 25: @@
 [[Category: Davies, G J.]]
 [[Category: Dennis, R J.]]
-[[Category: enzyme]]
+[[Category: Enzyme]]
-[[Category: gh84]]
+[[Category: Gh84]]
-[[Category: imidazole]]
+[[Category: Imidazole]]
-[[Category: inhibition]]
+[[Category: Inhibition]]
-[[Category: inhibitor]]
+[[Category: Inhibitor]]
-[[Category: o-glcnacase]]
+[[Category: O-glcnacase]]
-[[Category: pugnac]]
+[[Category: Pugnac]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:18:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:40 2008''