2j06: Difference between revisions

Revision as of 08:09, 4 May 2008

CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.8 ANGSTROM RESOLUTION

OverviewOverview

X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.

About this StructureAbout this Structure

2J06 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236 Page seeded by OCA on Sun May 4 08:09:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2j06.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2j06 |SIZE=350|CAPTION= <scene name='initialview01'>2j06</scene>, resolution 1.80&Aring;
+The line below this paragraph, containing "STRUCTURE_2j06", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2j06|  PDB=2j06  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j06 OCA], [http://www.ebi.ac.uk/pdbsum/2j06 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j06 RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.8 ANGSTROM RESOLUTION'''
@@ Line 28: / Line 25: @@
 [[Category: Kristensen, O.]]
 [[Category: Ross, B.]]
-[[Category: disease mutation]]
+[[Category: Disease mutation]]
-[[Category: gtpase activating protein]]
+[[Category: Gtpase activating protein]]
-[[Category: gtpase activation]]
+[[Category: Gtpase activation]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: proto-oncogene]]
+[[Category: Proto-oncogene]]
-[[Category: ras signaling pathway]]
+[[Category: Ras signaling pathway]]
-[[Category: sh2 domain]]
+[[Category: Sh2 domain]]
-[[Category: sh3 domain]]
+[[Category: Sh3 domain]]
-[[Category: signal transduction]]
+[[Category: Signal transduction]]
-[[Category: src homology 3]]
+[[Category: Src homology 3]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:09:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:51:14 2008''