2iug: Difference between revisions

Revision as of 07:53, 4 May 2008

CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN

OverviewOverview

Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.

About this StructureAbout this Structure

2IUG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes., Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC, Nat Struct Biol. 1996 Apr;3(4):364-74. PMID:8599763 Page seeded by OCA on Sun May 4 07:53:47 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2iug.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iug OCA], [http://www.ebi.ac.uk/pdbsum/2iug PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iug RCSB]</span>
-}}
 '''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN'''
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 [[Category: Schlessinger, J.]]
 [[Category: Shoelson, S E.]]
-[[Category: disease mutation]]
+[[Category: Disease mutation]]
-[[Category: p85]]
+[[Category: P85]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: pi3-kinase]]
+[[Category: Pi3-kinase]]
-[[Category: pi3k]]
+[[Category: Pi3k]]
-[[Category: polymorphism]]
+[[Category: Polymorphism]]
-[[Category: sh2]]
+[[Category: Sh2]]
-[[Category: sh2 domain]]
+[[Category: Sh2 domain]]
-[[Category: sh3 domain]]
+[[Category: Sh3 domain]]
-[[Category: transferase]]
+[[Category: Transferase]]
-[[Category: ubl conjugation]]
+[[Category: Ubl conjugation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:53:47 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:46 2008''