2v02: Difference between revisions
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==Overview== | ==Overview== | ||
Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans. | Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans. | ||
==Disease== | |||
Known diseases associated with this structure: Cavernous malformations of CNS and retina OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Cerebral cavernous malformations-1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Leukemia, acute T-cell lymphoblastic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603025 603025]], Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603025 603025]] | |||
==About this Structure== | ==About this Structure== | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
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Revision as of 00:34, 13 November 2007
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RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH BA
OverviewOverview
Calmodulin is a calcium sensor that is also capable of binding and being, activated by other metal ions. Of specific interest in this respect is, lead, which is known to be neurotoxic and to have a very high affinity, towards calmodulin. Crystal structures of human calmodulin complexed with, lead and barium ions have been solved. The results will help in, understanding the activation mechanisms of calmodulin by different heavy, metals and will provide a detailed view of a putative target for lead, neurotoxicity in humans.
DiseaseDisease
Known diseases associated with this structure: Cavernous malformations of CNS and retina OMIM:[604214], Cerebral cavernous malformations-1 OMIM:[604214], Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations OMIM:[604214], Leukemia, acute T-cell lymphoblastic OMIM:[603025], Leukemia, acute myeloid OMIM:[603025]
About this StructureAbout this Structure
2V02 is a Single protein structure of sequence from Homo sapiens with CA and BA as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
ReferenceReference
A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360
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