2hwq: Difference between revisions

Revision as of 06:48, 4 May 2008

Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists

OverviewOverview

Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.

About this StructureAbout this Structure

2HWQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists., Mahindroo N, Peng YH, Lin CH, Tan UK, Prakash E, Lien TW, Lu IL, Lee HJ, Hsu JT, Chen X, Liao CC, Lyu PC, Chao YS, Wu SY, Hsieh HP, J Med Chem. 2006 Oct 19;49(21):6421-4. PMID:17034149 Page seeded by OCA on Sun May 4 06:48:26 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2hwq.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2hwq |SIZE=350|CAPTION= <scene name='initialview01'>2hwq</scene>, resolution 1.97&Aring;
+The line below this paragraph, containing "STRUCTURE_2hwq", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DRY:[(1-{3-[(6-BENZOYL-1-PROPYL-2-NAPHTHYL)OXY]PROPYL}-1H-INDOL-5-YL)OXY]ACETIC+ACID'>DRY</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2hwq|  PDB=2hwq  |  SCENE=  }}
-|RELATEDENTRY=[[2hwr|2HWR]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwq OCA], [http://www.ebi.ac.uk/pdbsum/2hwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hwq RCSB]</span>
-}}
 '''Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists'''
@@ Line 31: / Line 28: @@
 [[Category: Peng, Y H.]]
 [[Category: Wu, S Y.]]
-[[Category: ligand binding protein]]
+[[Category: Ligand binding protein]]
-[[Category: ppar]]
+[[Category: Ppar]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:48:26 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:36:31 2008''