2ht6: Difference between revisions

Revision as of 06:40, 4 May 2008

Crystal structure of Human Gem G-domain bound to GDP

OverviewOverview

Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.

About this StructureAbout this Structure

2HT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure-function studies of the G-domain from human gem, a novel small G-protein., Opatowsky Y, Sasson Y, Shaked I, Ward Y, Chomsky-Hecht O, Litvak Y, Selinger Z, Kelly K, Hirsch JA, FEBS Lett. 2006 Oct 30;580(25):5959-64. Epub 2006 Oct 6. PMID:17052716 Page seeded by OCA on Sun May 4 06:40:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2ht6.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2ht6 |SIZE=350|CAPTION= <scene name='initialview01'>2ht6</scene>, resolution 2.400&Aring;
+The line below this paragraph, containing "STRUCTURE_2ht6", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= GEM, KIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2ht6|  PDB=2ht6  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ht6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ht6 OCA], [http://www.ebi.ac.uk/pdbsum/2ht6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ht6 RCSB]</span>
-}}
 '''Crystal structure of Human Gem G-domain bound to GDP'''
@@ Line 27: / Line 24: @@
 [[Category: Hirsch, J A.]]
 [[Category: Opatowsky, Y.]]
-[[Category: small g-protein]]
+[[Category: Small g-protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:40:50 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:03 2008''