2ht7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2ht7.gif|left|200px]] | [[Image:2ht7.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_2ht7", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
or leave the SCENE parameter empty for the default display. | |||
| | --> | ||
| | {{STRUCTURE_2ht7| PDB=2ht7 | SCENE= }} | ||
}} | |||
'''N8 neuraminidase in open complex with oseltamivir''' | '''N8 neuraminidase in open complex with oseltamivir''' | ||
| Line 35: | Line 32: | ||
[[Category: Skehel, J J.]] | [[Category: Skehel, J J.]] | ||
[[Category: Stevens, D J.]] | [[Category: Stevens, D J.]] | ||
[[Category: | [[Category: N8]] | ||
[[Category: | [[Category: Neuraminidase]] | ||
[[Category: | [[Category: Oseltamivir]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:40:48 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 06:40, 4 May 2008
N8 neuraminidase in open complex with oseltamivir
OverviewOverview
The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.
About this StructureAbout this Structure
2HT7 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design., Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ, Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235 Page seeded by OCA on Sun May 4 06:40:48 2008