2hcd: Difference between revisions

Revision as of 06:07, 4 May 2008

Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide

OverviewOverview

The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.

About this StructureAbout this Structure

2HCD is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

ReferenceReference

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092 Page seeded by OCA on Sun May 4 06:07:12 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2hcd.jpg|left|200px]]
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hcd OCA], [http://www.ebi.ac.uk/pdbsum/2hcd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hcd RCSB]</span>
-}}
 '''Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide'''
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 [[Category: Moras, D.]]
 [[Category: Rochel, N.]]
-[[Category: alpha helical sandwich]]
+[[Category: Alpha helical sandwich]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:07:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:26 2008''