2h2k: Difference between revisions

Revision as of 05:47, 4 May 2008

Crystal Structure Analysis of Human S100A13

OverviewOverview

The S100 protein family is the largest group of calcium-binding protein families, which consists of at least 25 members. S100A13, which is widely expressed in a variety of tissues, is a unique member of the S100 protein family. Previous reports showed that S100A13 might be involved in the stress-induced release of some signal peptide-less proteins (such as FGF-1 and IL-1alpha) and also associated with inflammatory functions. It was also reported that S100A13 is a new angiogenesis marker. Here we report the crystal structure of the Ca(2+)-bound form of S100A13 at 2.0 A resolution. S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. However, S100A13 has the unique structural feature with all alpha-helices being amphiphilic, which was not found in other members of S100s. We propose that this characteristic structure of S100A13 might be related to its ability to mediate the release of FGF-1 and IL-1alpha.

About this StructureAbout this Structure

2H2K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure study on human S100A13 at 2.0 A resolution., Li M, Zhang PF, Pan XW, Chang WR, Biochem Biophys Res Commun. 2007 May 11;356(3):616-21. Epub 2007 Mar 12. PMID:17374362 Page seeded by OCA on Sun May 4 05:47:51 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2h2k.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2h2k |SIZE=350|CAPTION= <scene name='initialview01'>2h2k</scene>, resolution 2.&Aring;
+The line below this paragraph, containing "STRUCTURE_2h2k", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2h2k|  PDB=2h2k  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h2k OCA], [http://www.ebi.ac.uk/pdbsum/2h2k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h2k RCSB]</span>
-}}
 '''Crystal Structure Analysis of Human S100A13'''
@@ Line 29: / Line 26: @@
 [[Category: Zhang, J P.]]
 [[Category: Zhang, P F.]]
-[[Category: calcium binding protein]]
+[[Category: Calcium binding protein]]
-[[Category: metal binding protein]]
+[[Category: Metal binding protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:47:51 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:24:36 2008''