2gv2: Difference between revisions

Revision as of 05:34, 4 May 2008

MDM2 in complex with an 8-mer p53 peptide analogue

OverviewOverview

The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.

About this StructureAbout this Structure

2GV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2., Sakurai K, Schubert C, Kahne D, J Am Chem Soc. 2006 Aug 30;128(34):11000-1. PMID:16925398 Page seeded by OCA on Sun May 4 05:34:22 2008

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OCA

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 [[Image:2gv2.gif|left|200px]]
- {{Structure
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-|GENE= MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2gv2|  PDB=2gv2  |  SCENE=  }}
-|RELATEDENTRY=[[1ycr|1YCR]], [[1t4f|1T4F]], [[1t4e|1T4E]], [[1rv1|1RV1]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gv2 OCA], [http://www.ebi.ac.uk/pdbsum/2gv2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gv2 RCSB]</span>
-}}
 '''MDM2 in complex with an 8-mer p53 peptide analogue'''
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 [[Category: Sakurai, K.]]
 [[Category: Schubert, C.]]
-[[Category: optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
+[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:34:22 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:58 2008''