2g9c: Difference between revisions

Revision as of 04:50, 4 May 2008

Modified pyrimidines Specifically bind the purine riboswitch

OverviewOverview

The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468 Page seeded by OCA on Sun May 4 04:50:43 2008

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OCA

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 [[Image:2g9c.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70&Aring;
+The line below this paragraph, containing "STRUCTURE_2g9c", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [http://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB]</span>
-}}
 '''Modified pyrimidines Specifically bind the purine riboswitch'''
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 ==About this Structure==
-G9C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].
 ==Reference==
 Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468]
-[[Category: Protein complex]]
 [[Category: Batey, R T.]]
 [[Category: Gilbert, S D.]]
 [[Category: Mediatore, S J.]]
-[[Category: mrna]]
+[[Category: Mrna]]
-[[Category: riboswitch]]
+[[Category: Riboswitch]]
-[[Category: rna-ligand complex]]
+[[Category: Rna-ligand complex]]
-[[Category: triaminopyrimidine]]
+[[Category: Triaminopyrimidine]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:50:43 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:32 2008''