2g7h: Difference between revisions

Revision as of 04:46, 4 May 2008

Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)

OverviewOverview

The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function.

About this StructureAbout this Structure

2G7H is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

ReferenceReference

Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase., Roberts A, Pelton JG, Wemmer DE, Magn Reson Chem. 2006 Jul;44 Spec No:S71-82. PMID:16826543 Page seeded by OCA on Sun May 4 04:46:46 2008

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OCA

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 [[Image:2g7h.gif|left|200px]]
- {{Structure
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-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= ogt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+-->
-|DOMAIN=
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7h OCA], [http://www.ebi.ac.uk/pdbsum/2g7h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g7h RCSB]</span>
-}}
 '''Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)'''
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 Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase., Roberts A, Pelton JG, Wemmer DE, Magn Reson Chem. 2006 Jul;44 Spec No:S71-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16826543 16826543]
 [[Category: Methanocaldococcus jannaschii]]
-[[Category: Methylated-DNA--[protein]-cysteine S-methyltransferase]]
 [[Category: Single protein]]
 [[Category: Roberts, A.]]
-[[Category: dna methyltransferase]]
+[[Category: Dna methyltransferase]]
-[[Category: dna repair]]
+[[Category: Dna repair]]
-[[Category: nmr]]
+[[Category: Nmr]]
-[[Category: protein structure]]
+[[Category: Protein structure]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:46:46 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:53 2008''