2f5h: Difference between revisions
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'''Solution structure of the alpha-domain of human Metallothionein-3''' | '''Solution structure of the alpha-domain of human Metallothionein-3''' | ||
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[[Category: Wu, H M.]] | [[Category: Wu, H M.]] | ||
[[Category: Zhang, Q.]] | [[Category: Zhang, Q.]] | ||
[[Category: | [[Category: Alpha helix]] | ||
[[Category: | [[Category: Cadmium-thiolate cluster]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:29:06 2008'' | |||
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Revision as of 03:29, 4 May 2008
Solution structure of the alpha-domain of human Metallothionein-3
OverviewOverview
Alzheimer's disease is characterized by progressive loss of neurons accompanied by the formation of intraneural neurofibrillary tangles and extracellular amyloid plaques. Human neuronal growth inhibitory factor, classified as metallothionein-3 (MT-3), was found to be related to the neurotrophic activity promoting cortical neuron survival and dendrite outgrowth in the cell culture studies. We have determined the solution structure of the alpha-domain of human MT-3 (residues 32-68) by multinuclear and multidimensional NMR spectroscopy in combination with the molecular dynamic simulated annealing approach. The human MT-3 shows two metal-thiolate clusters, one in the N-terminus (beta-domain) and one in the C-terminus (alpha-domain). The overall fold of the alpha-domain is similar to that of mouse MT-3. However, human MT-3 has a longer loop in the acidic hexapeptide insertion than that of mouse MT-3. Surprisingly, the backbone dynamics of the protein revealed that the beta-domain exhibits similar internal motion to the alpha-domain, although the N-terminal residues are more flexible. Our results may provide useful information for understanding the structure-function relationship of human MT-3.
About this StructureAbout this Structure
2F5H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure and dynamics of human metallothionein-3 (MT-3)., Wang H, Zhang Q, Cai B, Li H, Sze KH, Huang ZX, Wu HM, Sun H, FEBS Lett. 2006 Feb 6;580(3):795-800. Epub 2006 Jan 9. PMID:16413543 Page seeded by OCA on Sun May 4 03:29:06 2008