2f44: Difference between revisions

Revision as of 03:26, 4 May 2008

Crystal Structure of the Zinc-bound Shank SAM domain

OverviewOverview

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

About this StructureAbout this Structure

2F44 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662 Page seeded by OCA on Sun May 4 03:26:29 2008

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OCA

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 [[Image:2f44.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2f44 |SIZE=350|CAPTION= <scene name='initialview01'>2f44</scene>, resolution 2.4&Aring;
+The line below this paragraph, containing "STRUCTURE_2f44", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= Shank3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+-->
-|DOMAIN=
+{{STRUCTURE_2f44|  PDB=2f44  |  SCENE=  }}
-|RELATEDENTRY=[[2f3n|2F3N]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f44 OCA], [http://www.ebi.ac.uk/pdbsum/2f44 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f44 RCSB]</span>
-}}
 '''Crystal Structure of the Zinc-bound Shank SAM domain'''
@@ Line 28: / Line 25: @@
 [[Category: Bowie, J U.]]
 [[Category: Faham, S.]]
-[[Category: post-synaptic density]]
+[[Category: Post-synaptic density]]
-[[Category: sam domain]]
+[[Category: Sam domain]]
-[[Category: scaffolding protein]]
+[[Category: Scaffolding protein]]
-[[Category: shank]]
+[[Category: Shank]]
-[[Category: zinc]]
+[[Category: Zinc]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:26:29 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:40 2008''