2dvw: Difference between revisions

Revision as of 01:29, 4 May 2008

Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome

OverviewOverview

Gankyrin is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome and enhances the degradation of the tumor suppressors pRb and p53. Here, we report the structure of gankyrin in complex with the C-terminal domain of S6 ATPase. Almost all of the seven ankyrin repeats of gankyrin interact, through its concave region, with the C-terminal domain of S6 ATPase. The intermolecular interactions occur through the complementary charged residues between gankyrin and S6 ATPase. Biochemical studies based on the structure of the complex revealed that gankyrin interacts with pRb in both the presence and absence of S6 ATPase; however, the E182 residue in gankyrin is essential for the pRb interaction. These results provide a structural basis for the involvement of gankyrin in the pRb degradation pathway, through its association with S6 ATPase of the 26S proteasome.

About this StructureAbout this Structure

2DVW is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome., Nakamura Y, Nakano K, Umehara T, Kimura M, Hayashizaki Y, Tanaka A, Horikoshi M, Padmanabhan B, Yokoyama S, Structure. 2007 Feb;15(2):179-89. PMID:17292836 Page seeded by OCA on Sun May 4 01:29:27 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2dvw.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2dvw |SIZE=350|CAPTION= <scene name='initialview01'>2dvw</scene>, resolution 2.30&Aring;
+The line below this paragraph, containing "STRUCTURE_2dvw", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= Psmd10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), PSMC4, TBP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2dvw|  PDB=2dvw  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvw OCA], [http://www.ebi.ac.uk/pdbsum/2dvw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dvw RCSB]</span>
-}}
 '''Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome'''
@@ Line 29: / Line 26: @@
 [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
 [[Category: Yokoyama, S.]]
-[[Category: a-helical domain]]
+[[Category: A-helical domain]]
-[[Category: ankyrin repeat]]
+[[Category: Ankyrin repeat]]
-[[Category: national project on protein structural and functional analyse]]
+[[Category: National project on protein structural and functional analyse]]
-[[Category: nppsfa]]
+[[Category: Nppsfa]]
-[[Category: riken structural genomics/proteomics initiative]]
+[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
+[[Category: Rsgi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 01:29:27 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:16 2008''