2d2z: Difference between revisions

Revision as of 23:36, 3 May 2008

Crystal structure of Soluble Form Of CLIC4

OverviewOverview

The crystal structure of a wild type of the human soluble chloride intracellular ion channel CLIC4 (wCLIC4) has been determined at a resolution of 2.2A. The structure shows a homotrimer in an asymmetric unit, which is first observed in CLICs. The assembly of the trimer takes a unique triple interaction mode between three monomers with a hydrogen-bond network and hydrophobic contacts. Through such complicated interactions, the homotrimer of wCLIC4 is firmly stabilized. The structure shows an oligomeric mode with a unique assembly mechanism by which the oligomerization of CLIC4 can be performed without any intramolecular disulfide bond formation. It indicated a possibility that CLIC4 may take a unique structural organization distinct from CLIC1 for docking with lipid bilayers. In addition, the structure shows distinct conformational states of the h2 region for respective monomers of the trimer, which reveal an intrinsic conformational susceptibility for this significant region in the structural transition.

About this StructureAbout this Structure

2D2Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals., Li Y, Li D, Zeng Z, Wang D, Biochem Biophys Res Commun. 2006 May 19;343(4):1272-8. Epub 2006 Mar 27. PMID:16581025 Page seeded by OCA on Sat May 3 23:36:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2d2z.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2d2z |SIZE=350|CAPTION= <scene name='initialview01'>2d2z</scene>, resolution 2.2&Aring;
+The line below this paragraph, containing "STRUCTURE_2d2z", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2d2z|  PDB=2d2z  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2z OCA], [http://www.ebi.ac.uk/pdbsum/2d2z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d2z RCSB]</span>
-}}
 '''Crystal structure of Soluble Form Of CLIC4'''
@@ Line 28: / Line 25: @@
 [[Category: Li, Y F.]]
 [[Category: Wang, D C.]]
-[[Category: clic4]]
+[[Category: Clic4]]
-[[Category: crystal structure]]
+[[Category: Crystal structure]]
-[[Category: soluble form]]
+[[Category: Soluble form]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:36:15 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:29:38 2008''