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'''Crystal structure of Superoxide dismutase from P. Marinus''' | '''Crystal structure of Superoxide dismutase from P. Marinus''' | ||
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[[Category: Silva, A M.]] | [[Category: Silva, A M.]] | ||
[[Category: Vasta, G R.]] | [[Category: Vasta, G R.]] | ||
[[Category: | [[Category: Sod]] | ||
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Revision as of 23:11, 3 May 2008
Crystal structure of Superoxide dismutase from P. Marinus
OverviewOverview
Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.
About this StructureAbout this Structure
2CW2 is a Single protein structure of sequence from Perkinsus marinus. Full crystallographic information is available from OCA.
ReferenceReference
Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:17077482 Page seeded by OCA on Sat May 3 23:11:09 2008