2c6b: Difference between revisions

Revision as of 21:19, 3 May 2008

SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2

OverviewOverview

HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.

About this StructureAbout this Structure

2C6B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008 Page seeded by OCA on Sat May 3 21:19:23 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:2c6b.gif|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_2c6b", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
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-|DOMAIN=
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6b OCA], [http://www.ebi.ac.uk/pdbsum/2c6b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c6b RCSB]</span>
-}}
 '''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''
@@ Line 30: / Line 27: @@
 [[Category: Fersht, A R.]]
 [[Category: Yu, G W.]]
-[[Category: alternative splicing]]
+[[Category: Alternative splicing]]
-[[Category: human mdm2]]
+[[Category: Human mdm2]]
-[[Category: ligase]]
+[[Category: Ligase]]
-[[Category: metal-binding]]
+[[Category: Metal-binding]]
-[[Category: nuclear protein]]
+[[Category: Nuclear protein]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: proto-oncogene]]
+[[Category: Proto-oncogene]]
-[[Category: ubl conjugation pathway]]
+[[Category: Ubl conjugation pathway]]
-[[Category: zinc]]
+[[Category: Zinc]]
-[[Category: zinc finger]]
+[[Category: Zinc finger]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:19:23 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:57 2008''