2bve: Difference between revisions

Revision as of 20:51, 3 May 2008

STRUCTURE OF THE N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH 2-PHENYL-PROP5AC

OverviewOverview

The Siglec family of receptors mediates cell-surface interactions through recognition of sialylated glycoconjugates. Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding. To characterize further the carbohydrate-binding properties, we have determined the crystal structures of SnD1 in the absence of ligand, and in complex with 2-benzyl-Neu5NPro and 2-benzyl-Neu5NAc. These structures reveal that SnD1 undergoes very few structural changes on ligand binding and detail how two novel classes of sialic acid analogs bind, one of which unexpectedly can induce Siglec dimerization. In conjunction with in silico analysis, this set of structures informs us about the design of putative ligands with enhanced binding affinities and specificities to different Siglecs, and provides data with which to test the effectiveness of different computational drug design protocols.

About this StructureAbout this Structure

2BVE is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin., Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY, J Mol Biol. 2007 Feb 2;365(5):1469-79. Epub 2006 Oct 28. PMID:17137591 Page seeded by OCA on Sat May 3 20:51:17 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2bve.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2bve |SIZE=350|CAPTION= <scene name='initialview01'>2bve</scene>, resolution 2.20&Aring;
+The line below this paragraph, containing "STRUCTURE_2bve", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Ph5+Binding+Site+For+Chain+B'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=PH5:2-PHENYL-PROP5AC'>PH5</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2bve|  PDB=2bve  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bve OCA], [http://www.ebi.ac.uk/pdbsum/2bve PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bve RCSB]</span>
-}}
 '''STRUCTURE OF THE N-TERMINAL OF SIALOADHESIN IN COMPLEX WITH 2-PHENYL-PROP5AC'''
@@ Line 33: / Line 30: @@
 [[Category: Robinson, R C.]]
 [[Category: Zaccai, N R.]]
-[[Category: carbohydrate binding]]
+[[Category: Carbohydrate binding]]
-[[Category: cell adhesion]]
+[[Category: Cell adhesion]]
-[[Category: immune system]]
+[[Category: Immune system]]
-[[Category: immunoglobulin superfamily]]
+[[Category: Immunoglobulin superfamily]]
-[[Category: inhibitor design]]
+[[Category: Inhibitor design]]
-[[Category: siglec]]
+[[Category: Siglec]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:51:17 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:12:19 2008''