2b1a: Difference between revisions

Revision as of 19:43, 3 May 2008

Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide

OverviewOverview

Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.

About this StructureAbout this Structure

2B1A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:16731948 Page seeded by OCA on Sat May 3 19:43:47 2008

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OCA

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 [[Image:2b1a.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1a OCA], [http://www.ebi.ac.uk/pdbsum/2b1a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b1a RCSB]</span>
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 '''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG1033 peptide'''
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 [[Category: Wilson, I A.]]
 [[Category: Zolla-Pazner, S.]]
-[[Category: fab-peptide complex]]
+[[Category: Fab-peptide complex]]
-[[Category: gp120]]
+[[Category: Gp120]]
-[[Category: hiv-1]]
+[[Category: Hiv-1]]
-[[Category: v3 loop]]
+[[Category: V3 loop]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:43:47 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:07 2008''