2ar6: Difference between revisions

Revision as of 19:22, 3 May 2008

Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592

OverviewOverview

The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.

About this StructureAbout this Structure

2AR6 is a Single protein structure of sequence from Pterocarpus angolensis. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin., Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R, FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415 Page seeded by OCA on Sat May 3 19:22:19 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2ar6.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2ar6 |SIZE=350|CAPTION= <scene name='initialview01'>2ar6</scene>, resolution 1.8&Aring;
+The line below this paragraph, containing "STRUCTURE_2ar6", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2ar6|  PDB=2ar6  |  SCENE=  }}
-|RELATEDENTRY=[[1q8o|1Q8O]], [[1n3o|1N3O]], [[1s1a|1S1A]], [[2arb|2ARB]], [[2are|2ARE]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ar6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ar6 OCA], [http://www.ebi.ac.uk/pdbsum/2ar6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ar6 RCSB]</span>
-}}
 '''Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592'''
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 [[Category: Versees, W.#.]]
 [[Category: Wyns, L.]]
-[[Category: carbohydrate recognition]]
+[[Category: Carbohydrate recognition]]
-[[Category: lectin]]
+[[Category: Lectin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:22:19 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:56:13 2008''