2adu: Difference between revisions

Revision as of 18:55, 3 May 2008

Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor

OverviewOverview

Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of interest as potential treatments for cancer. A new class of small molecule reversible inhibitors of hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor of cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor was also shown to inhibit angiogenesis in vivo.

About this StructureAbout this Structure

2ADU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo., Kallander LS, Lu Q, Chen W, Tomaszek T, Yang G, Tew D, Meek TD, Hofmann GA, Schulz-Pritchard CK, Smith WW, Janson CA, Ryan MD, Zhang GF, Johanson KO, Kirkpatrick RB, Ho TF, Fisher PW, Mattern MR, Johnson RK, Hansbury MJ, Winkler JD, Ward KW, Veber DF, Thompson SK, J Med Chem. 2005 Sep 8;48(18):5644-7. PMID:16134930 Page seeded by OCA on Sat May 3 18:55:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2adu.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2adu |SIZE=350|CAPTION= <scene name='initialview01'>2adu</scene>, resolution 1.90&Aring;
+The line below this paragraph, containing "STRUCTURE_2adu", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=R20:4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE'>R20</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= METAP2, MNPEP, P67EIF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2adu|  PDB=2adu  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adu OCA], [http://www.ebi.ac.uk/pdbsum/2adu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2adu RCSB]</span>
-}}
 '''Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor'''
@@ Line 50: / Line 47: @@
 [[Category: Yang, G.]]
 [[Category: Zhang, G F.]]
-[[Category: aminopeptidase]]
+[[Category: Aminopeptidase]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: metal binding]]
+[[Category: Metal binding]]
-[[Category: protease]]
+[[Category: Protease]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:55:15 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:14 2008''