2a91: Difference between revisions

Revision as of 18:45, 3 May 2008

Crystal structure of ErbB2 domains 1-3

OverviewOverview

ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.

About this StructureAbout this Structure

2A91 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors., Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW, Mol Cell. 2003 Feb;11(2):495-505. PMID:12620236 Page seeded by OCA on Sat May 3 18:45:46 2008

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OCA

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 [[Image:2a91.gif|left|200px]]
- {{Structure
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-}}
 '''Crystal structure of ErbB2 domains 1-3'''
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 [[Category: McKern, N M.]]
 [[Category: Nice, E C.]]
-[[Category: cell-surface receptor]]
+[[Category: Cell-surface receptor]]
-[[Category: tyrosine kinase receptor]]
+[[Category: Tyrosine kinase receptor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:45:46 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:49:28 2008''