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'''Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus''' | '''Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus''' | ||
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[[Category: Yaver, D.]] | [[Category: Yaver, D.]] | ||
[[Category: Zasloff, M.]] | [[Category: Zasloff, M.]] | ||
[[Category: | [[Category: Defensin,antimicrobial peptide,cysteine stabilized alpha-beta motif]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:34:20 2008'' | |||
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Revision as of 17:34, 3 May 2008
Plectasin:A peptide antibiotic with therapeutic potential from a saprophytic fungus
OverviewOverview
Animals and higher plants express endogenous peptide antibiotics called defensins. These small cysteine-rich peptides are active against bacteria, fungi and viruses. Here we describe plectasin-the first defensin to be isolated from a fungus, the saprophytic ascomycete Pseudoplectania nigrella. Plectasin has primary, secondary and tertiary structures that closely resemble those of defensins found in spiders, scorpions, dragonflies and mussels. Recombinant plectasin was produced at a very high, and commercially viable, yield and purity. In vitro, the recombinant peptide was especially active against Streptococcus pneumoniae, including strains resistant to conventional antibiotics. Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin. These findings identify fungi as a novel source of antimicrobial defensins, and show the therapeutic potential of plectasin. They also suggest that the defensins of insects, molluscs and fungi arose from a common ancestral gene.
About this StructureAbout this Structure
1ZFU is a Single protein structure of sequence from Pseudoplectania nigrella. Full crystallographic information is available from OCA.
ReferenceReference
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus., Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sonksen CP, Ludvigsen S, Raventos D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jorgensen SG, Sorensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH, Nature. 2005 Oct 13;437(7061):975-80. PMID:16222292 Page seeded by OCA on Sat May 3 17:34:20 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Pseudoplectania nigrella
- Single protein
- Buskov, S.
- Christensen, B.
- Christensen, B E.
- Elvig-Jorgensen, S G.
- Fischer, R L.
- Frimodt-Moller, N.
- Hansen, M T.
- Kjaerulf, S.
- Kristensen, H H.
- Lehrer, R I.
- Ludvigsen, S.
- Maria, L De.
- Mygind, P H.
- Raventos, D.
- Schnorr, K.
- Sonksen, C P.
- Sorensen, M V.
- Taboureau, O.
- Yaver, D.
- Zasloff, M.
- Defensin,antimicrobial peptide,cysteine stabilized alpha-beta motif