1zbd: Difference between revisions

Revision as of 17:25, 3 May 2008

STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A

OverviewOverview

The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The first interface involves the Rab3A switch I and switch II regions, which are sensitive to the nucleotide-binding state of Rab3A. The second interface consists of a deep pocket in Rab3A that interacts with a SGAWFF structural element of rabphilin-3A. Sequence and structure analysis, and biochemical data suggest that this pocket, or Rab complementarity-determining region (RabCDR), establishes a specific interaction between each Rab protein and its effectors. RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion.

About this StructureAbout this Structure

1ZBD is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A., Ostermeier C, Brunger AT, Cell. 1999 Feb 5;96(3):363-74. PMID:10025402 Page seeded by OCA on Sat May 3 17:25:01 2008

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OCA

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 [[Image:1zbd.gif|left|200px]]
- {{Structure
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 '''STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A'''
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 [[Category: Brunger, A T.]]
 [[Category: Ostermeier, C.]]
-[[Category: effector]]
+[[Category: Effector]]
-[[Category: g protein]]
+[[Category: G protein]]
-[[Category: rab protein]]
+[[Category: Rab protein]]
-[[Category: rab3a]]
+[[Category: Rab3a]]
-[[Category: rabcdr]]
+[[Category: Rabcdr]]
-[[Category: rabphilin]]
+[[Category: Rabphilin]]
-[[Category: synaptic exocytosis]]
+[[Category: Synaptic exocytosis]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 17:25:01 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:33:34 2008''