1yxq: Difference between revisions

Revision as of 16:56, 3 May 2008

Crystal structure of actin in complex with swinholide A

OverviewOverview

Marine toxins targeting the actin cytoskeleton represent a new and promising class of anti-cancer compounds. Here we present a 2.0 A resolution structure of swinholide A, a marine macrolide, bound to two actin molecules. The structure demonstrates that the actin dimer in the complex does not represent a physiologically relevant entity, for the two actin molecules do not interact with each other. The swinholide A actin binding site is the same as that targeted by toxins of the trisoxazole family and numerous actin binding proteins, highlighting the importance of this site in actin polymerization. The observed structure reveals the mechanism of action of swinholide A and provides a structural framework about which to design new agents directed at the cytoskeleton.

About this StructureAbout this Structure

1YXQ is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of swinholide A binding to actin., Klenchin VA, King R, Tanaka J, Marriott G, Rayment I, Chem Biol. 2005 Mar;12(3):287-91. PMID:15797212 Page seeded by OCA on Sat May 3 16:55:59 2008

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OCA

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 [[Image:1yxq.gif|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_1yxq", creates the "Structure Box" on the page.
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxq OCA], [http://www.ebi.ac.uk/pdbsum/1yxq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yxq RCSB]</span>
-}}
 '''Crystal structure of actin in complex with swinholide A'''
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 [[Category: Rayment, I.]]
 [[Category: Tanaka, J.]]
-[[Category: actin]]
+[[Category: Actin]]
-[[Category: macrolide toxin]]
+[[Category: Macrolide toxin]]
-[[Category: swinholide some]]
+[[Category: Swinholide some]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:55:59 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:26:05 2008''