1yu3: Difference between revisions
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'''Major Tropism Determinant I1 Variant''' | '''Major Tropism Determinant I1 Variant''' | ||
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[[Category: McMahon, S A.]] | [[Category: McMahon, S A.]] | ||
[[Category: Miller, J L.]] | [[Category: Miller, J L.]] | ||
[[Category: | [[Category: Beta prism]] | ||
[[Category: | [[Category: Beta sandwich]] | ||
[[Category: | [[Category: C-type lectin]] | ||
[[Category: | [[Category: Diversity-generating retroelement]] | ||
[[Category: | [[Category: Variability]] | ||
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Revision as of 16:47, 3 May 2008
Major Tropism Determinant I1 Variant
OverviewOverview
Only few instances are known of protein folds that tolerate massive sequence variation for the sake of binding diversity. The most extensively characterized is the immunoglobulin fold. We now add to this the C-type lectin (CLec) fold, as found in the major tropism determinant (Mtd), a retroelement-encoded receptor-binding protein of Bordetella bacteriophage. Variation in Mtd, with its approximately 10(13) possible sequences, enables phage adaptation to Bordetella spp. Mtd is an intertwined, pyramid-shaped trimer, with variable residues organized by its CLec fold into discrete receptor-binding sites. The CLec fold provides a highly static scaffold for combinatorial display of variable residues, probably reflecting a different evolutionary solution for balancing diversity against stability from that in the immunoglobulin fold. Mtd variants are biased toward the receptor pertactin, and there is evidence that the CLec fold is used broadly for sequence variation by related retroelements.
About this StructureAbout this Structure
1YU3 is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.
ReferenceReference
The C-type lectin fold as an evolutionary solution for massive sequence variation., McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P, Nat Struct Mol Biol. 2005 Oct;12(10):886-92. Epub 2005 Sep 18. PMID:16170324 Page seeded by OCA on Sat May 3 16:47:28 2008