1ym5: Difference between revisions

Revision as of 16:30, 3 May 2008

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.

OverviewOverview

In the Pseudomonas bacterial genomes, the PhzF proteins are involved in the production of phenazine derivative antibiotic and antifungal compounds. The PhzF superfamily however also encompasses proteins in all genomes from bacteria to eukaryotes, for which no function has been assigned. We have determined the three dimensional crystal structure at 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a fold similar to bacterial diaminopimelate epimerase, revealing a bimodular structure with an internal symmetry. Residue conservation identifies a putative active site at the interface between the two domains. Evolution of this protein by gene duplication, gene fusion and domain swapping from an ancestral gene containing the "hot dog" fold, identifies the protein as a "kinked double hot dog" fold.

About this StructureAbout this Structure

1YM5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily., Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N, Proteins. 2005 Sep 1;60(4):778-86. PMID:16021630 Page seeded by OCA on Sat May 3 16:29:59 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1ym5.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ym5 |SIZE=350|CAPTION= <scene name='initialview01'>1ym5</scene>, resolution 2.05&Aring;
+The line below this paragraph, containing "STRUCTURE_1ym5", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1ym5|  PDB=1ym5  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ym5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ym5 OCA], [http://www.ebi.ac.uk/pdbsum/1ym5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ym5 RCSB]</span>
-}}
 '''Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.'''
@@ Line 35: / Line 32: @@
 [[Category: Tilbeurgh, H Van.]]
 [[Category: YSG, Paris-Sud Yeast Structural Genomics.]]
-[[Category: double hot-dog]]
+[[Category: Double hot-dog]]
-[[Category: paris-sud yeast structural genomic]]
+[[Category: Paris-sud yeast structural genomic]]
-[[Category: phzf enzyme superfamily]]
+[[Category: Phzf enzyme superfamily]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
-[[Category: ysg]]
+[[Category: Ysg]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:29:59 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:12:59 2008''