1xsn: Difference between revisions

Revision as of 15:27, 3 May 2008

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP

OverviewOverview

Pol lambda is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol lambda representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol lambda does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction.

About this StructureAbout this Structure

1XSN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

A closed conformation for the Pol lambda catalytic cycle., Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:15608652 Page seeded by OCA on Sat May 3 15:27:44 2008

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OCA

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 [[Image:1xsn.gif|left|200px]]
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 '''Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP'''
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 [[Category: Kunkel, T A.]]
 [[Category: Pedersen, L C.]]
-[[Category: dna polymerase lambda]]
+[[Category: Dna polymerase lambda]]
-[[Category: helix-hairpin-helix]]
+[[Category: Helix-hairpin-helix]]
-[[Category: protein-dna complex]]
+[[Category: Protein-dna complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:27:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:08 2008''