1xp9: Difference between revisions

Revision as of 15:19, 3 May 2008

HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18

OverviewOverview

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

About this StructureAbout this Structure

1XP9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers., Blizzard TA, Dininno F, Morgan JD 2nd, Chen HY, Wu JY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Fitzgerald PM, Sharma N, Li Y, Zhang Z, Hayes EC, Dasilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML, Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. PMID:15582421 Page seeded by OCA on Sat May 3 15:19:39 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1xp9.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1xp9 |SIZE=350|CAPTION= <scene name='initialview01'>1xp9</scene>, resolution 1.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1xp9", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=AIJ:(2S,3R)-3-(4-HYDROXYPHENYL)-2-(4-{[(2S)-2-PYRROLIDIN-1-YLPROPYL]OXY}PHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL'>AIJ</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= ESR1, NR3A1, ESR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_1xp9|  PDB=1xp9  |  SCENE=  }}
-|RELATEDENTRY=[[1xp1|1XP1]], [[1xp6|1XP6]], [[1xpc|1XPC]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp9 OCA], [http://www.ebi.ac.uk/pdbsum/1xp9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xp9 RCSB]</span>
-}}
 '''HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18'''
@@ Line 27: / Line 24: @@
 [[Category: Fitzgerald, P M.D.]]
 [[Category: Sharma, N.]]
-[[Category: antagonist]]
+[[Category: Antagonist]]
-[[Category: er-alpha]]
+[[Category: Er-alpha]]
-[[Category: nuclear receptor]]
+[[Category: Nuclear receptor]]
-[[Category: transcription factor]]
+[[Category: Transcription factor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:19:39 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:43 2008''