1xoi: Difference between revisions

Revision as of 15:17, 3 May 2008

Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide

OverviewOverview

The synthesis, in vitro, and in vivo biological characterization of a series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver glycogen phosphorylase A are described. Improved potency over previously reported compounds in cellular and in vivo assays was observed. The allosteric binding site of these compounds was shown by X-ray crystallography to be the same as that reported previously for 5-chloroindoloyl norstatine amides.

About this StructureAbout this Structure

1XOI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization., Wright SW, Rath VL, Genereux PE, Hageman DL, Levy CB, McClure LD, McCoid SC, McPherson RK, Schelhorn TM, Wilder DE, Zavadoski WJ, Gibbs EM, Treadway JL, Bioorg Med Chem Lett. 2005 Jan 17;15(2):459-65. PMID:15603973 Page seeded by OCA on Sat May 3 15:17:53 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1xoi.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1xoi |SIZE=350|CAPTION= <scene name='initialview01'>1xoi</scene>, resolution 2.1&Aring;
+The line below this paragraph, containing "STRUCTURE_1xoi", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=288:5-CHLORO-1H-INDOLE-2-CARBOXYLIC+ACID{[CYCLOPENTYL-(2-HYDROXY-ETHYL)-CARBAMOYL]-METHYL}-AMIDE'>288</scene>, <scene name='pdbligand=NBG:1-N-ACETYL-BETA-D-GLUCOSAMINE'>NBG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1xoi|  PDB=1xoi  |  SCENE=  }}
-|RELATEDENTRY=[[1em6|1EM6]], [[1exv|1EXV]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xoi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xoi OCA], [http://www.ebi.ac.uk/pdbsum/1xoi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xoi RCSB]</span>
-}}
 '''Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide'''
@@ Line 30: / Line 27: @@
 [[Category: Treadway, J L.]]
 [[Category: Wright, S W.]]
-[[Category: allosteric enzyme]]
+[[Category: Allosteric enzyme]]
-[[Category: glycogen storage disease]]
+[[Category: Glycogen storage disease]]
-[[Category: glycosyltransferase]]
+[[Category: Glycosyltransferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:17:53 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:27 2008''