1xie: Difference between revisions

Revision as of 15:04, 3 May 2008

MODES OF BINDING SUBSTRATES AND THEIR ANALOGUES TO THE ENZYME D-XYLOSE ISOMERASE

OverviewOverview

Studies of binding of substrates and inhibitors of the enzyme D-xylose isomerase show, from X-ray diffraction data at 1.6-1.9 A resolution, that there are a variety of binding modes. These vary in the manner in which the substrate or its analogue extend, on binding, across the carboxy end of the (betaalpha)(8)-barrel structure. These binding sites are His54 and the metal ion (magnesium or manganese) that is held in place by Glul81, Asp245, Glu217 and Asp287. Possible catalytic groups have been identified in proposed mechanisms and their role in the binding of ligands is illustrated.

About this StructureAbout this Structure

1XIE is a Single protein structure of sequence from Streptomyces rubiginosus. Full crystallographic information is available from OCA.

ReferenceReference

Modes of binding substrates and their analogues to the enzyme D-xylose isomerase., Carrell HL, Hoier H, Glusker JP, Acta Crystallogr D Biol Crystallogr. 1994 Mar 1;50(Pt 2):113-23. PMID:15299449 Page seeded by OCA on Sat May 3 15:04:29 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1xie.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1xie |SIZE=350|CAPTION= <scene name='initialview01'>1xie</scene>, resolution 1.7&Aring;
+The line below this paragraph, containing "STRUCTURE_1xie", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=ASO:1,5-ANHYDROSORBITOL'>ASO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Xylose_isomerase Xylose isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.5 5.3.1.5] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1xie|  PDB=1xie  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xie OCA], [http://www.ebi.ac.uk/pdbsum/1xie PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xie RCSB]</span>
-}}
 '''MODES OF BINDING SUBSTRATES AND THEIR ANALOGUES TO THE ENZYME D-XYLOSE ISOMERASE'''
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 [[Category: Carrell, H L.]]
 [[Category: Glusker, J P.]]
-[[Category: isomerase(intramolecular oxidoreductse)]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:04:29 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:02 2008''