1xfh: Difference between revisions

Revision as of 14:57, 3 May 2008

Structure of glutamate transporter homolog from Pyrococcus horikoshii

OverviewOverview

Glutamate transporters are integral membrane proteins that catalyse the concentrative uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion gradients. In the central nervous system glutamate transporters are essential for normal development and function, and are implicated in stroke, epilepsy and neurodegenerative diseases. Here we present the crystal structure of a eukaryotic glutamate transporter homologue from Pyrococcus horikoshii. The transporter is a bowl-shaped trimer with a solvent-filled extracellular basin extending halfway across the membrane bilayer. At the bottom of the basin are three independent binding sites, each cradled by two helical hairpins, reaching from opposite sides of the membrane. We propose that transport of glutamate is achieved by movements of the hairpins that allow alternating access to either side of the membrane.

About this StructureAbout this Structure

1XFH is a Single protein structure of sequence from Pyrococcus horikoshii ot3. Full crystallographic information is available from OCA.

ReferenceReference

Structure of a glutamate transporter homologue from Pyrococcus horikoshii., Yernool D, Boudker O, Jin Y, Gouaux E, Nature. 2004 Oct 14;431(7010):811-8. PMID:15483603 Page seeded by OCA on Sat May 3 14:57:43 2008

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OCA

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-|GENE= GltPh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii OT3])
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 '''Structure of glutamate transporter homolog from Pyrococcus horikoshii'''
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-[[Category: trimeric helical transmembrane protein]]
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