1x9t: Difference between revisions

Revision as of 14:45, 3 May 2008

The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide

OverviewOverview

The adenovirus penton, a noncovalent complex of the pentameric penton base and trimeric fiber proteins, comprises the vertices of the adenovirus capsid and contains all necessary components for viral attachment and internalization. The 3.3 A resolution crystal structure of human adenovirus 2 (hAd2) penton base shows that the monomer has a basal jellyroll domain and a distal irregular domain formed by two long insertions, a similar topology to the adenovirus hexon. The Arg-Gly-Asp (RGD) motif, required for interactions with cellular integrins, occurs on a flexible surface loop. The complex of penton base with bound N-terminal fiber peptide, determined at 3.5 A resolution, shows that the universal fiber motif FNPVYPY binds at the interface of adjacent penton base monomers and results in a localized structural rearrangement in the insertion domain of the penton base. These results give insight into the structure and assembly of the adenovirus capsid and will be of use for gene-therapy applications.

About this StructureAbout this Structure

1X9T is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the human adenovirus 2 penton., Zubieta C, Schoehn G, Chroboczek J, Cusack S, Mol Cell. 2005 Jan 7;17(1):121-35. PMID:15629723 Page seeded by OCA on Sat May 3 14:45:17 2008

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OCA

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 [[Image:1x9t.gif|left|200px]]
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-|GENE= penton base ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2])
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 '''The crystal structure of human adenovirus 2 penton base in complex with an ad2 N-terminal fibre peptide'''
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 [[Category: Schoehn, G.]]
 [[Category: Zubieta, C.]]
-[[Category: anti-parallel beta sheet]]
+[[Category: Anti-parallel beta sheet]]
-[[Category: insertion domain]]
+[[Category: Insertion domain]]
-[[Category: jellyroll domain]]
+[[Category: Jellyroll domain]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:45:17 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:46:42 2008''