1x95: Difference between revisions

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[[Image:1x95.gif|left|200px]]
[[Image:1x95.gif|left|200px]]


{{Structure
<!--
|PDB= 1x95 |SIZE=350|CAPTION= <scene name='initialview01'>1x95</scene>
The line below this paragraph, containing "STRUCTURE_1x95", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=XR2:1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM'>XR2</scene>
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|ACTIVITY=  
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|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1x95| PDB=1x95  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x95 OCA], [http://www.ebi.ac.uk/pdbsum/1x95 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x95 RCSB]</span>
}}


'''solution structure of the B-DNA hexamer ATGCAT complexed with MLN944, a bisphenazine anticancer drug'''
'''solution structure of the B-DNA hexamer ATGCAT complexed with MLN944, a bisphenazine anticancer drug'''
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==About this Structure==
==About this Structure==
1X95 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X95 OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X95 OCA].  


==Reference==
==Reference==
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug., Dai J, Punchihewa C, Mistry P, Ooi AT, Yang D, J Biol Chem. 2004 Oct 29;279(44):46096-103. Epub 2004 Aug 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317822 15317822]
Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug., Dai J, Punchihewa C, Mistry P, Ooi AT, Yang D, J Biol Chem. 2004 Oct 29;279(44):46096-103. Epub 2004 Aug 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317822 15317822]
[[Category: Protein complex]]
[[Category: Dai, J.]]
[[Category: Dai, J.]]
[[Category: Mistry, P.]]
[[Category: Mistry, P.]]
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[[Category: Punchihewa, C.]]
[[Category: Punchihewa, C.]]
[[Category: Yang, D.]]
[[Category: Yang, D.]]
[[Category: anticancer drug]]
[[Category: Anticancer drug]]
[[Category: ap-1]]
[[Category: Ap-1]]
[[Category: mln944]]
[[Category: Mln944]]
[[Category: nmr]]
[[Category: Nmr]]
[[Category: novel dna binding]]
[[Category: Novel dna binding]]
[[Category: structure]]
[[Category: Structure]]
[[Category: transcription inhibition]]
[[Category: Transcription inhibition]]
 
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