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'''CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN''' | '''CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN''' | ||
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[[Category: Liang, D C.]] | [[Category: Liang, D C.]] | ||
[[Category: Wan, Z L.]] | [[Category: Wan, Z L.]] | ||
[[Category: | [[Category: Hormone]] | ||
[[Category: | [[Category: Insulin]] | ||
[[Category: | [[Category: Phenol]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:23:56 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 13:23, 3 May 2008
CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN
OverviewOverview
The form-B monoclinic insulin crystal was obtained from the sodium citrate buffer with 1% zinc chloride, keeping phenolic content between 0.76% and 1.25%. Its space group is P2(1), cell constants are: a = 4.924 nm, b = 6.094 nm, c = 4.818 nm, beta = 95.8 degrees. There are 6 insulin molecules which form a hexamer. The initial phase was obtained by using rotation function program of X-PLOR program package and molecular packing program of our laboratory. The molecular model was chosen from 4 zinc bovine insulin hexamer. After the preliminary refinement by using the macromolecular rigid body refinement technique, the molecular model was further refined and adjusted by using the energy-minimizing stereochemically restrained least-squared refinement on the difference Fourier maps. The final R-factor is 22.4% at 0.3 nm resolution, the r.m.s. deviations from standard bond length and bond angle are 0.0022 nm and 4.7 degrees, respectively.
About this StructureAbout this Structure
1WAV is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.
ReferenceReference
Molecular replacement study on form-B monoclinic crystal of insulin., Ding J, Wan Z, Chang W, Liang D, Sci China C Life Sci. 1996 Apr;39(2):144-53. PMID:8760462 Page seeded by OCA on Sat May 3 13:23:56 2008