1w7x: Difference between revisions

Revision as of 13:16, 3 May 2008

FACTOR7- 413 COMPLEX

OverviewOverview

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.

About this StructureAbout this Structure

1W7X is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138 Page seeded by OCA on Sat May 3 13:16:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1w7x.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1w7x |SIZE=350|CAPTION= <scene name='initialview01'>1w7x</scene>, resolution 1.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1w7x", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+H'>AC1</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=413:(S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC+ACID'>413</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1w7x|  PDB=1w7x  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7x OCA], [http://www.ebi.ac.uk/pdbsum/1w7x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w7x RCSB]</span>
-}}
 '''FACTOR7- 413 COMPLEX'''
@@ Line 40: / Line 37: @@
 [[Category: Weber, L.]]
 [[Category: Wessel, H P.]]
-[[Category: coagulation]]
+[[Category: Coagulation]]
-[[Category: enzyme complex]]
+[[Category: Enzyme complex]]
-[[Category: serine protease]]
+[[Category: Serine protease]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:16:54 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:28 2008''