1vok: Difference between revisions

Revision as of 12:44, 3 May 2008

ARABIDOPSIS THALIANA TBP (DIMER)

OverviewOverview

The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic alpha-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.

About this StructureAbout this Structure

1VOK is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

ReferenceReference

2.1 A resolution refined structure of a TATA box-binding protein (TBP)., Nikolov DB, Burley SK, Nat Struct Biol. 1994 Sep;1(9):621-37. PMID:7634102 Page seeded by OCA on Sat May 3 12:44:12 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1vok.jpg|left|200px]]
- {{Structure
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 '''ARABIDOPSIS THALIANA TBP (DIMER)'''
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 [[Category: Burley, S K.]]
 [[Category: Nikolov, D B.]]
-[[Category: dna binding]]
+[[Category: Dna binding]]
-[[Category: transcription factor]]
+[[Category: Transcription factor]]
-[[Category: transcription initiation]]
+[[Category: Transcription initiation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:44:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:26:35 2008''