1vln: Difference between revisions

Revision as of 12:41, 3 May 2008

A TRICLINIC CRYSTAL FORM OF THE LECTIN CONCANAVALIN A

OverviewOverview

The molecular structure of a triclinic crystal form of concanavalin A has been refined at 2.4 A resolution. The crystals have unit cell dimensions a = 78.8 A, b = 79.3 A, c = 133.3 A, alpha = 97.1degrees, beta = 90.2degrees, and gamma = 97.5degrees and contain two tetramers per asymmetric unit each with approximate 222 symmetry. The final crystallographic R-factor is 0.205 and the free-R-factor is 0.265 in the resolution range 6.0 to 2.4 A. The conformation of the tetramer is more similar to that found in concanavalin A saccharide complexes than in the previously reported I222 crystal form of uncomplexed concanavalin A. A comparison of the molecular packing between the two crystal forms shows a more open arrangement with large solvent channels through the crystal.

About this StructureAbout this Structure

1VLN is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

ReferenceReference

A Triclinic Crystal Form of the Lectin Concanavalin A, Kanellopoulos PN, Tucker PA, Pavlou K, Agianian B, Hamodrakas SJ, J Struct Biol. 1996 Jul;117(1):16-23. PMID:8812975 Page seeded by OCA on Sat May 3 12:41:21 2008

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OCA

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 [[Category: Kanellopoulos, P N.]]
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-[[Category: calcium]]
+[[Category: Calcium]]
-[[Category: lectin]]
+[[Category: Lectin]]
-[[Category: legume]]
+[[Category: Legume]]
-[[Category: manganese]]
+[[Category: Manganese]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:41:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:26:06 2008''