1v3d: Difference between revisions

Revision as of 12:01, 3 May 2008

Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN

OverviewOverview

The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface.

About this StructureAbout this Structure

1V3D is a Single protein structure of sequence from Human parainfluenza virus 3. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III., Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM, J Mol Biol. 2004 Jan 30;335(5):1343-57. PMID:14729348 Page seeded by OCA on Sat May 3 12:01:39 2008

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OCA

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 [[Image:1v3d.gif|left|200px]]
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-|RELATEDENTRY=[[1v2i|1V2I]], [[1v3b|1V3B]], [[1v3c|1V3C]], [[1v3e|1V3E]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v3d OCA], [http://www.ebi.ac.uk/pdbsum/1v3d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v3d RCSB]</span>
-}}
 '''Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with NEU5AC2EN'''
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 [[Category: Streltsov, V A.]]
 [[Category: Varghese, J N.]]
-[[Category: hexagonal]]
+[[Category: Hexagonal]]
-[[Category: native+neu5ac2en]]
+[[Category: Native+neu5ac2en]]
-[[Category: piv3 hn]]
+[[Category: Piv3 hn]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:01:39 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:18:56 2008''